Song Parodies -> "Phenylalanine"

Original Song Title:

"Yellow Submarine"

Original Performer:

"Phenylalanine"

Parody Written by:

The Lyrics

How do you prevent an SH2-domain containing protein from being recruited to a partner protein? Tyrosine-to-phenylalanine!

In the lab where I did work
On some SH2 proteins
And they liked to bind real tight
To some phosphotyrosines

So to stop them from binding
With a kit from Stratagene
DNA we did mutate
Now it's phenylalanine

Tyrosine into phenylalanine!
Phenyalanine! Phenylalanine!
They can't bind to phenylalanine!
Phenylalanine, phenylalanine!

So we mutate four or more
Interactions nevermore
Nobel Prizes on our way!

(Trumpets)

Now we'll star in Nature Magazine!
Phenylalanine, changed from tyrosine!
Should we worry about the threonines?
That would be obscene! Phenylalanine!

(PCR it, Dr. Rice Cube, PCR it!
We got a band here, sir!
Bacteria! Bacteria!
Alright, transfect!
Success! Success!)

As we finish our IPs (lysis please!)
Every Western blot (Western blot) for PLC (PLC!)
SH2 (SH2) cannot be seen (can't be seen!)
With our phenyl (phenyl) alanine (alanine HAHA!)

Now we'll star in Nature Magazine!
Phenylalanine, changed from tyrosine!
Should we worry about the threonines?
That would be obscene! Phenylalanine!

Tyrosine into phenylalanine!
Phenyalanine! Phenylalanine!
They can't bind to phenylalanine!
Phenylalanine, phenylalanine!

http://en.wikipedia.org/wiki/SH2_domain

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TJC - January 13, 2010 - Report this comment

You've turned those "mean old acids" into something truly special! I'd give you a standing ovation, but my 'chair configuration's' resisting that kind of action... No worries--sitll folding you fives from home!

Old Man Ribber - January 13, 2010 - Report this comment

Who says there's no intellectual content on this site? Your DNA humor has Watson up the Crick without a paddle! ;D

Jeff Reuben - January 13, 2010 - Report this comment

I'm in the field...this was brilliant! Definitely sending this around work :-)

Rice Cube - January 13, 2010 - Report this comment

Didn't know you were a biologist Jeff. Thanks for the kind words.

Phil Alexander - January 13, 2010 - Report this comment

More than two decades since I was in a biochem lab.. but I can still pronounce the words :-)

Kristof Robertson - January 13, 2010 - Report this comment

Now my head hurts!!! Wow, good to see 2 names from the dim distant past floating ashore on Amiright island again. Great stuff 555

Tommy Turtle - January 13, 2010 - Report this comment

Wouldn't it be more fun to ethylate that to PEA, the "love molecule"? ... then methylate at the alpha position, and .... Nice to see TT isn't the only egghead on the site. Vote: 22B.

Ann Hammond - January 18, 2010 - Report this comment

My head hurts too

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